功能食品与葡萄酒学院
食品质量与安全教研室
食品质量与安全教研室
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杜易洋
日期:2024-03-04 10:55:58 来源:功能食品与葡萄酒学院

杜易洋,博士,副教授,食品质量与安全教研室主任兼教工党支部书记2012年毕业于沈阳药科大学,获药物(英语)学士学位,2012-2017硕博连读,获沈阳药科大学药物分析博士学位作为课题负责人主持国家自然科学基金1项,辽宁省教育厅科研项目1项,沈阳药科大学中青年教师事业发展支持计划1项。另外,获省级本科教学改革研究优质教学资源建设与共享项目1项,共发表SCI收载论文数十篇。

   人才称号、社会兼职等

      1. 沈阳市高级人才;

   主要研究方向

   研究方向一:药食同源品药效物质基础

   研究方向二:功能食品功效因子筛选与评价

   主持、参与的科研项目(含科研获奖等情况)

1. 1. 基于TLR4-NFκB/NLRP3Wnt/β-Catenin信号通路的crosstalk调控“肠道菌群--脑”轴探讨酸枣仁汤改善抑郁症的药效物质基础和作用机制,国家自然科学基金青年科学基金项目,基金编号82003926(负责人)

2. 2. 酸枣仁汤基于“肠-脑”轴相关性的抗抑郁药效物质基础及作用机制研究,辽宁省教育厅博士基金启动项目,基金编号2019BS229(负责人)

3. 酸枣仁颗粒剂临床前研究,科技部重大专项,基金编号2014ZX09304306-007(参与人)

   近年来发表代表性论文(限第一作者或通讯作者,SCI须写明影响因子)

1. Yiyang Du, Jiahong Wang, Li Jiang, Jinyan Li, Jiahe Li, Chuang Ren, Tingxu Yan, Ying Jia, Bosai He,* Screening the components in multi-biological samples and the comparative pharmacokinetic study in healthy and depression model rats of Suan-Zao-Ren decoction combined with a network pharmacology. Journal of Ethnopharmacology 319 (2024) 117360 (IF 5.40)

2. Yiyang Du, Tingxu Yan, Bo Wu, Bosai He**, Ying Jia* Research on the mechanism of antidepressive effect of Suanzaoren Decoction through TLR4/MyD88/NF-κB pathway and Wnt/β-catenin pathway. Journal of Ethnopharmacology 319 (2024) 117190. (IF 5.40)

3. Xiaoying Zhang, Wenjuan Liu, Shuanglin Zhang, Jinyu Wang, Xihan Yang, Ruixuan Wang, Tingxu Yan, Bo Wu, Yiyang Du**, Ying Jia*. Wei-Tong-Xin ameliorates functional dyspepsia via inactivating TLR4/MyD88 by regulating gut microbial structure and metabolites. Phytomedicine 2022, 102,154180 (IF 7.9)

4. Tian Tian, Zheng Huang, Yiyang Du**, Longshan Zhao*. Efficient degradation of tetracycline in a photo-Fenton system constructed by combining MOF-derived FeO/C/InO heterojunction with vitamin C. Journal of Alloys and Compounds 968 (2023) 172048. (IF 6.2)

5. Yiyang Du , Bosai He , Bo Wu, Tingxu Yan *, Ying Jia *. Suanzaoren decoction improves depressive-like behaviors by regulating the microbiota-gut-brain axis via inhibiting TLR4/NFκB/NLRP3 inflammation signal pathway. Journal of Chemical Neuroanatomy 134 (2023) 102349 (IF 2.8)

6. Du Y, Wu B, Xiao F, Yan T, Jia Y, Bi K, He B*, A systematic data screening strategy for comprehensive characterization of chemical components in Suan-Zao-Ren decoction and their metabolic profiles in the plasma and brain of rats using ultra high performance liquid chromatography quadrupole time-of-flight mass spectrometry, Analytical Methods, 2019, 11,5533-5542.IF=2.596

7. Du Y, Wu B, Xiao F, Yan T, Li Q, Jia Y, Bi K, He B*, Untargeted metabolomic study on the insomnia effect of Suan-Zao-Ren decoction in the rat serum and brain using ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry combined with data processing analysis, Journal of Separation Science, 2020 Jun;43(11):2019-2030.IF=3.645

8. Yiyang Du, Bosai He, Qing Li, Jiao He, Di Wang, Kaishun Bi. Identification and analysis of chemical constituents and rat serum metabolites in Suan-Zao-Ren granule using ultra high performance liquid chromatography quadrupole time-of-flight mass spectrometry combined with multiple data processing approaches. J Sep Sci. 2017, 40(14):2914-2924. (IF 2.741)

9. Yiyang Du, Bosai He, Qing Li, Jiao He, Di Wang, Kaishun Bi. Simultaneous determination of multiple active components in rat plasma using ultra-fast liquid chromatography-tandem mass spectrometry method and application to a comparative pharmacokinetic study after oral administration of Suan-Zao-Ren decoction and Suan-Zao-Ren granule. J Sep Sci. 2017, 40(10):2097-2106. (IF 2.741)

10. Yiyang Du, Qing Li, Jingjing Liu, Yidi Yin, Kaishun Bi. Combinative method using multi-components quantitation by single reference standard and HPLC fingerprint for comprehensive evaluation of Rhodiola crenulata H.Ohba. Anal. Methods. 2014, 6, 5891-5898. (IF 1.915)

   主编或参编的教材、专著

1. 中医方证代谢组学研究进展2021年卷),编委。