一、个人简介

颜廷旭，男，1984年生，沈阳药科大学生药学博士，任教于沈阳药科大学功能食品与葡萄酒学院食品质量与安全教研室，特聘副教授。2006年毕业于沈阳药科大学，获药物制剂学士学位，2009年于同校获药剂学硕士学位，2018年获沈阳药科大学生药学博士学位。2019年7月入江苏康缘药业有限公司博士后工作站开展博士后研究工作。2018年12月被聘为沈阳药科大学特聘副教授。作为课题负责人主持了辽宁省科技厅项目1项，中国博士后科学基金面上资助项目1项，江苏省博士后科研资助计划项目1项，沈阳药科大学博士启动基金1项，沈阳药科大学国自然培育基金1项。目前已在Food Func, Int J Biol Macromol等期刊发表论文30余篇。

二、研究方向

研究方向一：神经退行性疾病的中药干预

研究方向二：功能食品功效因子筛选与评价

研究方向三：新功能食品开发

三、社会兼职

辽宁省食品科学技术学会青年委员；

Journal of Polyphenols编委；

四、科研项目

1.五味子总木脂素重塑机体氮平衡整体调节肠-肝-脑轴多靶点协同抗抑郁作用机制研究，中国博士后科学基金面上资助项目，基金编号2020M681518（负责人）

2.基于肠道菌群介导的五味子抗抑郁作用机制研究，辽宁省博士科研启动基金计划项目，基金编号2019-BS-233（负责人）

3.2018年，沈阳市自然科学学术成果奖（学术论文类）三等奖（排名第一）

五、近年来发表第一作者代表性文章

1.Tingxu Yan, Tingting Nian, Zhengzheng Liao, Feng Xiao, Bo Wu, Kaishun Bi, Bosai He, and Ying Jia*. Antidepressant effects of a polysaccharide from okra (Abelmoschus esculentus (L) Moench) by anti-inflammation and rebalancing the gut microbiota. International Journal of Biological Macromolecules. 2020, 144:427-440 (IF:5.162)

2.Tingxu Yan, Nizhi Wang, Bing Liu, Bo Wu, Feng Xiao, Bosai He, Ying Jia*. Schisandra chinensis ameliorates depressive-like behaviors by regulating microbiota-gut-brain axis via its anti-inflammation activity. Phytotherapy Research. 2020, 10.1002/ptr.6799. (IF: 4.087)

3.TingxuYan, TingtingNian, BoWu, FengXiao, BosaiHe, KaishunBi, YingJia*. Okra polysaccharides can reverse the metabolic disorder induced by high-fat diet and cognitive function injury in Aβ1–42 mice. Experimental Gerontology, 130 (2020):110802. (IF:3.376)

4.Tingxu Yan, Yingying Sun, Feng Xiao, Bo Wu, Kaishun Bi, Bosai He, Ying Jia*. Schisandrae Chinensis Fructus inhibits behavioral deficits induced by sleep deprivation and chronic unpredictable mild stress via increased signaling of brain‐derived neurotrophic factor. Phytotherapy Research. 2019, 33(12):3177-3190. (IF: 4.087)

5.Tingxu Yan, Bosai He, Mengjie Xu, Bo Wu, Feng Xiao, Kaishun Bi, Ying Jia*. Kaempferide prevents cognitive decline via attenuation of oxidative stress and enhancement of brain‐derived neurotrophic factor/tropomyosin receptor kinase B/cAMP response element-binding signaling pathway. Phytotherapy Reasearch 2019:1-9.(IF: 4.087)

6.Tingxu Yan, Fuyuan Li, Weilin Xiong, Bo Wu, Feng Xiao, Bosai He, Ying Jia*. Nootkatone improves anxiety‐and depression‐like behavior by targeting hyperammonemia-induced oxidative stress in D-galactosamine model of liver injury. Environmental Toxicology https://doi.org/10.1002/tox.23073 (IF:3.118)

7.Yingying Sun^#,Tingxu Yan^#, Guowei Gong, Yue Li, Jingying Zhang, Bo Wu, Kaishun Bi, Ying Jia*. Antidepressant-like effects of Schisandrin on lipopolysaccharide-induced mice: Gut microbiota, short chain fatty acid and TLR4/NF-κB signaling pathway. Int Immunopharmacol. 2020 Oct 9;89(Pt A):107029. doi: 10.1016/j.intimp.2020.107029. (IF:3.943)

8.Tingxu Yan, Yingying Sun, Guowei Gong, Yue Li, Kaiyue Fan, Bo Wu, Kaishun Bi, Ying Jia*. The neuroprotective effect of Schisandrol A on 6-OHDA-induced PD mice may be related to PI3K/AKT and IKK/IκBα/NF-κB pathway. Experimental Gerontology, 128 (2019): 110743. (IF:3.376)

9.Mengjie Xu^#,Tingxu Yan^#, Guowei Gong, Bo Wu, Bosai He, Yiyang Du, Feng Xiao*, Ying Jia*.Purification, structural characterization, and cognitive improvement activity of a polysaccharides from Schisandra chinensis. International Journal of Biological Macromolecules. 10.1016/j.ijbiomac.2020.06.275. (IF:5.162)

10.Tingxu Yan, Bing Liu, Nizhi Wang, Zhengzheng Liao, Bo Wu, Bosai He, Ying Jia* The flavonoids of okra insulates against oxidative stress, neuroinflammation and restores BDNF levels in Aβ induced mouse model of Alzheimer's disease.Environmental Toxicology, 2021, 147: 111263.(IF:3.118).