张晓书，副教授，硕士研究生导师，沈阳药科大学功能食品与葡萄酒学院副院长。长期从事绞股蓝、龙葵、海棠等药用食品的物质基础及功效评价的研究。作为课题负责人主持国家自然科学基金青年基金1项，辽宁省科技厅自然科学基金面上项目2项，辽宁教育厅项目3项。沈阳药科大学中青年教师事业发展支持计划2项，辽宁省大学生创新训练项目8项。2024年辽宁省优秀硕士学位论文指导教师，并连续两届获得功能食品与葡萄酒学院讲课大赛一等奖。另外，作为主要完成人参与国家“十一五”重大专项1项，国家“十一五”重大专项子平台项目1项，其他省、市级科研项目4项。兼任《Journal of Polyphenols》编委、《中草药》、《沈阳药科大学学报》等期刊青年编委。相关研究内容发表在《Food Research International》、《Journal of Agricultural and Food Chemistry》、《Journal of Functional Food》等SCI论文30余篇，其中中科院一区论文10篇，包括2篇影响因子10以上的论文。主要承担《功能食品学》、《新食品原料与特殊营养食品》及《保健食品质量与安全评价》等课程。

代表性科研成果：

1. Ting Gao¹, Meng Zhang¹, Minjie Li, Wenhan Yao, Wenjie Shu, Weizhuo Tang, Xiaoshu Zhang*. Nuezhenoside G13 from Osmanthus fragrans fruit ameliorates Concanavalin A-induced autoimmune hepatitis by regulating the NF-κB/MAPK pathway. Journal of Ethnopharmacology. 2024, 319:117257, IF: 5.4.

2. Xueying Wang, Ziqi Sun, Xiaoli Wang, Minjie Li, Boru Zhou, Xiaoshu Zhang*，Solanum nigrum L. berries extract ameliorated the alcoholic liver injury by regulating gut microbiota, lipid metabolism, inflammation, and oxidative stress. Food Research International, 2024, 188: 114489, IF:8.2.

3. Ting Gao, Minjie Li, Meng Zhang, Yuxi Xiang, Zilong Huang, Weizhuo Tang*, Xiaoshu Zhang*, Balanophora dioica ethanol extract ameliorates isoproterenol-induced myocardial injury by suppressing ffbrosis, inffammation and apoptosis by regulating TLR4/MyD88/NF-κB signaling pathway. Arabian Journal of Chemistry. 2024, 17: 105662, IF: 6.1.

4. Zhaoxu Meng¹, Xiaoshu Zhang¹, Hongyan Tan, He Lian*. Zinc-enriched nanosystem for dual glycolysis regulation and photothermal therapy to synergistically inhibit primary melanoma and lung metastasis, Chemical Engineering Journal, 2022, 435: 134781, IF:16.844.

5. Hongyan Tan, Minjie Li, Linlin Han, Yuqing Zhao* and Xiaoshu Zhang*. Gypensapogenin I Suppresses Cell Proliferation in Triple-Negative Breast Cancer Via Triggering the Closure of AKT/GSK3β/β-Catenin and Notch-1 Signaling Pathways. Journal of Agricultural and Food Chemistry, 2022, 70:5438-5449, IF:6.1.

6. Lei Xu,§ Shengnan Xiao,§ Jung Joon Lee, Hua Jiang, Xiaofei Li, Xiaoshu Zhang* and Yuqing Zhao*. In Vivo Metabolites of Panaxadiol Inhibit HepG-2 Cell Proliferation by Inducing G1 Arrest and ROS-Mediated Apoptosis. Journal of Agricultural and Food Chemistry, 2022, 70(37): 11560-11571, IF:6.1.

7. Hongyan Tan, Meng Zhang, Lei Xu, Xiaoshu Zhang*, Yuqing Zhao*. Gypensapogenin H suppresses tumor growth and cell migration in triple-negative breast cancer by regulating PI3K/AKT/NF-κB/MMP-9 signaling pathway. Bioorganic Chemistry. 2022, 126:105913, IF 5.307.

8. He Lian, Ping Guan, Hongyan Tan, Xiaoshu Zhang*, Zhaoxu Meng**. Near-infrared light triggered multi-hit therapeutic nanosystem for tumor specifc photothermal effect amplifed signal pathway regulation and ferroptosis. Bioactive Materials. 2022, 9:63-76. IF:18.9.

9. Lei Xu¹, Xiaoshu Zhang¹, Shengnan Xiao, Xiaofei Li, Hua Jiang, Ziyi Wang, Baoshan Sun*, Yuqing Zhao*. Panaxadiol as a major metabolite of AD-1 can significantly inhibit the proliferation and migration of breast cancer cells: In vitro and in vivo study. Bioorganic Chemistry, 2021, 116: 105392. IF 5.307.