杜易洋,女,博士,副教授,食品质量与安全教研室主任兼教工党支部书记。2012年毕业于沈阳药科大学,获药物(英语)学士学位,2012年-2017年硕博连读,获沈阳药科大学药物分析博士学位。作为课题负责人主持国家自然科学基金1项,辽宁省教育厅科研项目1项,沈阳药科大学中青年教师事业发展支持计划1项。另外,获省级本科教学改革研究优质教学资源建设与共享项目1项,共发表SCI收载论文数十篇。
人才称号、社会兼职等
1. 沈阳市高级人才;
主要研究方向
研究方向一:药食同源品药效物质基础
研究方向二:功能食品功效因子筛选与评价
主持、参与的科研项目(含科研获奖等情况)
1. 1. 基于TLR4-NFκB/NLRP3和Wnt/β-Catenin信号通路的crosstalk调控“肠道菌群-肠-脑”轴探讨酸枣仁汤改善抑郁症的药效物质基础和作用机制,国家自然科学基金青年科学基金项目,基金编号82003926(负责人)
2. 2. 酸枣仁汤基于“肠-脑”轴相关性的抗抑郁药效物质基础及作用机制研究,辽宁省教育厅博士基金启动项目,基金编号2019BS229(负责人)
3. 酸枣仁颗粒剂临床前研究,科技部重大专项,基金编号2014ZX09304306-007(参与人)
近年来发表代表性论文(限第一作者或通讯作者,SCI须写明影响因子)
1. Yiyang Du, Jiahong Wang, Li Jiang, Jinyan Li, Jiahe Li, Chuang Ren, Tingxu Yan, Ying Jia, Bosai He,* Screening the components in multi-biological samples and the comparative pharmacokinetic study in healthy and depression model rats of Suan-Zao-Ren decoction combined with a network pharmacology. Journal of Ethnopharmacology 319 (2024) 117360 (IF 5.40)
2. Yiyang Du, Tingxu Yan, Bo Wu, Bosai He**, Ying Jia* Research on the mechanism of antidepressive effect of Suanzaoren Decoction through TLR4/MyD88/NF-κB pathway and Wnt/β-catenin pathway. Journal of Ethnopharmacology 319 (2024) 117190. (IF 5.40)
3. Xiaoying Zhang, Wenjuan Liu, Shuanglin Zhang, Jinyu Wang, Xihan Yang, Ruixuan Wang, Tingxu Yan, Bo Wu, Yiyang Du**, Ying Jia*. Wei-Tong-Xin ameliorates functional dyspepsia via inactivating TLR4/MyD88 by regulating gut microbial structure and metabolites. Phytomedicine 2022, 102,154180 (IF 7.9)
4. Tian Tian, Zheng Huang, Yiyang Du**, Longshan Zhao*. Efficient degradation of tetracycline in a photo-Fenton system constructed by combining MOF-derived FeO/C/InO heterojunction with vitamin C. Journal of Alloys and Compounds 968 (2023) 172048. (IF 6.2)
5. Yiyang Du , Bosai He , Bo Wu, Tingxu Yan *, Ying Jia *. Suanzaoren decoction improves depressive-like behaviors by regulating the microbiota-gut-brain axis via inhibiting TLR4/NFκB/NLRP3 inflammation signal pathway. Journal of Chemical Neuroanatomy 134 (2023) 102349 (IF 2.8)
6. Du Y, Wu B, Xiao F, Yan T, Jia Y, Bi K, He B*, A systematic data screening strategy for comprehensive characterization of chemical components in Suan-Zao-Ren decoction and their metabolic profiles in the plasma and brain of rats using ultra high performance liquid chromatography quadrupole time-of-flight mass spectrometry, Analytical Methods, 2019, 11,5533-5542.(IF=2.596)
7. Du Y, Wu B, Xiao F, Yan T, Li Q, Jia Y, Bi K, He B*, Untargeted metabolomic study on the insomnia effect of Suan-Zao-Ren decoction in the rat serum and brain using ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry combined with data processing analysis, Journal of Separation Science, 2020 Jun;43(11):2019-2030.(IF=3.645)
8. Yiyang Du, Bosai He, Qing Li, Jiao He, Di Wang, Kaishun Bi. Identification and analysis of chemical constituents and rat serum metabolites in Suan-Zao-Ren granule using ultra high performance liquid chromatography quadrupole time-of-flight mass spectrometry combined with multiple data processing approaches. J Sep Sci. 2017, 40(14):2914-2924. (IF 2.741)
9. Yiyang Du, Bosai He, Qing Li, Jiao He, Di Wang, Kaishun Bi. Simultaneous determination of multiple active components in rat plasma using ultra-fast liquid chromatography-tandem mass spectrometry method and application to a comparative pharmacokinetic study after oral administration of Suan-Zao-Ren decoction and Suan-Zao-Ren granule. J Sep Sci. 2017, 40(10):2097-2106. (IF 2.741)
10. Yiyang Du, Qing Li, Jingjing Liu, Yidi Yin, Kaishun Bi. Combinative method using multi-components quantitation by single reference standard and HPLC fingerprint for comprehensive evaluation of Rhodiola crenulata H.Ohba. Anal. Methods. 2014, 6, 5891-5898. (IF 1.915)
主编或参编的教材、专著
1. 中医方证代谢组学研究进展(2021年卷),编委。