个人情况介绍、概览

颜廷旭，博士，副教授，硕士生导师，入围美国斯坦福大学和爱思唯尔数据库发布2023全球前2％顶尖科学家榜单。作为课题负责人主持国家自然科学基金面上项目1项，中国博士后科学基金面上资助项目1项，辽宁省科技厅博士启动项目1项，辽宁省教育厅面上项目2项，江苏省博士后科研资助计划项目1项，沈阳药科大学博士启动基金1项，沈阳药科大学国自然培育基金1项等。相关科研成果已发表SCI论文50余篇，并于2020年获沈阳市自然学术成果三等奖。

人才称号、社会兼职等

1.辽宁省“兴辽英才计划”青年拔尖人才；

2.沈阳市高级人才

3.本溪市高级人才（第三层次）

4.国家食品审评中心特殊食品注册审评核查专家

5.国家自然科学基金函审评议专家

6.中国优生优育协会儿童成长与特殊食品专业委员会常委

7.辽宁省食品科学技术学会青年委员

8.Journal of Future Foods杂志青年编委

9.Journal of Polyphenols杂志编委；

主要研究方向

研究方向一：神经退行性疾病的中药干预

研究方向二：功能食品功效因子筛选与评价

研究方向三：新功能食品开发

主持、参与的科研项目

1.五味子调控机体内源性大麻素系统参与“肠脑对话”的抗抑郁物质基础与作用机制研究，国家自然科学基金面上项目，82173961，负责人；

2.五味子基于ECS系统调控神经炎症的抗抑郁物质基础与作用机制研究，“兴辽英才计划”青年拔尖人才项目，XLYC2203200，负责人；

3.五味子总木脂素重塑机体氮平衡整体调节肠-肝-脑轴多靶点协同抗抑郁作用机制研究，中国博士后科学基金第68批面上资助，2020M681518，负责人；

4.基于肠道菌群介导的五味子抗抑郁作用机制研究，辽宁省博士科研启动基金计划项目，2019-BS-233，负责人；

5.五味子总木脂素重塑机体氮平衡抗抑郁作用机制研究，辽宁省教育厅面上项目，LJKZ0950，负责人；

6.大株红景天胶囊调控线粒体自噬改善MIRI作用机制研究，江苏省博士后科研资助计划资助，2020Z149，负责人

7.2018年沈阳市自然科学学术成果奖（学术论文类）三等奖（排名第一）

近年来发表代表性论文

1.Jinyu Wang, Aijuan Zheng, Fei Lin, Xiaozhuo Zhang, Kaifang Shi,Tingxu Yan*, Ying Jia*, Schisandra chinensis lignans regulate and cooperate with endogenous cannabinoid systems to ameliorate intestinal barrier injury associated with depression, Phytomedicine, 2024, 155929,中科院1区IF:6.7

2.Ruixuan Wang, Youdong Zhao, Lei Zhou, Fei Lin, Meiqi Wan, Anna Gan, Bo Wu,Tingxu Yan*, and Ying Jia*.Costunolide ameliorates MNNG-induced chronic atrophic gastritis through inhibiting oxidative stress and DNA damage via activation of Nrf2.Phytomedicine, 130: 155581 doi.org/10.1016/j.phymed.2024.155581.中科院1区IF:6.7

3.Xiaoying Zhang, Shiyu Wang, Yanjun Jin, Jinyu Wang, Ruixuan Wang, Xihan Yang, Shuanglin Zhang,Tingxu Yan*, and Ying Jia*,Wei-Tong-Xin ameliorated cisplatin-induced mitophagy and apoptosis in gastric antral mucosa by activating the Nrf2/HO-1 pathway. Journal of Ethnopharmacology. 2023, 308: 116253.中科院1区IF:5.4

4.Fei Lin, Guanglin Zhang, Xihan Yang, Mengshi Wang, Ruixuan Wang, Meiqi Wan, Jinyu Wang, Bo Wu,Tingxu Yan*, and Ying Jia*, A network pharmacology approach and experimental validation to investigate the anticancer mechanism and potential active targets of ethanol extract of Wei-Tong-Xin against colorectal cancer through induction of apoptosis via PI3K/AKT signaling pathway, Journal of Ethnopharmacology, 2023, 303: 115933,中科院1区IF:5.4

5.Mengjie Xu, Yunfang Yang, Jing Peng, Yue Zhang, Bo Wu, Bosai He, Ying Jia*,Tingxu Yan*, Effects of Alpinae Oxyphyllae Fructus on microglial polarization in a LPS-induced BV2 cells model of neuroinflammation via TREM2, Journal of Ethnopharmacology, 2023, 302: 115914.中科院1区IF:5.4

6.Jinyu Wang, Guanglin Zhang, Yunfang Yang, Xiaoying Zhang, Kaifang Shi, Xiaozhuo Zhang,Tingxu Yan*, and Ying Jia*，Schisandra chinensis Lignans Exert Antidepressant Effects by Promoting BV2 Microglia Polarization toward the M2 Phenotype through the Activation of the Cannabinoid Receptor Type-2–Signal Transducer and Activator of Transcription 6 Pathway. Journal of Agricultural and Food Chemistry, 2022 , 70: 14157−14169中科院1区IF:6.1

7.Wenjuan Liu, Xiaoying Zhang, Tiancheng Ma, Jinyu Wang, Xinyan Lv, Bo Wu,Tingxu Yan*, Ying Jia*. Uncovering the pharmacological mechanism of Wei-Tong-Xin against gastric ulcer based on network pharmacology combined with in vivo experiment validation. Journal of Ethnopharmacology. 2022; 293: 115282.中科院1区IF:5.4

8.Tingxu Yan, Qianqian Mao, Xiaozhuo Zhang, Bo Wu, Kaishun Bi, Bosai He and Ying Jia. Schisandra chinensis protects against dopaminergic neuronal oxidative stress, neuroinflammation and apoptosis via the BDNF/Nrf2/NF-κB pathway in 6-OHDA-induced Parkinson’s disease mice. Food & Function, 2021, 12: 4079-4091.中科院1区IF：6.317

9.Tingxu Yan, Nizhi Wang, Bing Liu, Bo Wu, Feng Xiao, Bosai He, Ying Jia*. Schisandra chinensis ameliorates depressive-like behaviors by regulating microbiota-gut-brain axis via its anti-inflammation activity. Phytotherapy Research. 2021, 35: 289-296.中科院2区，IF: 6.388

10.Tingxu Yan, Tingting Nian, Zhengzheng Liao, Feng Xiao, Bo Wu, Kaishun Bi, Bosai He, and Ying Jia*. Antidepressant effects of a polysaccharide from okra (Abelmoschus esculentus (L) Moench) by anti-inflammation and rebalancing the gut microbiota. International Journal of Biological Macromolecules. 2020, 144:427-440中科院1区，IF:6.953