张晓书，女，博士，副教授，2014年毕业于沈阳药科大学，获博士学位，2015年留校任教，主要研究方向为功能食品的物质基础及作用机制研究等。作为课题负责人主持国家自然科学基金青年基金1项，辽宁省教育科技向目1项，沈阳药科大学中青年教师事业发展支持计划1项，辽宁省大学生创新训练项目1项。另外，作为主要完成人参与国家“十一五”重大专项1项，国家“十一五”重大专项子平台项目1项，其他省、市级科研项目4项。目前已在Journal of Functional Food, Phytochemistry, Journal of Agricultural and Food Chemistry等期刊发表论文20余篇。

主要研究方向

研究方向一：保健食品及功能性食品的物质基础研究

研究方向二：具有抗乳腺癌的天然功能因子的发现与制备

研究方向三：抗乳腺癌活性成分的发现及作用机制研究

主持、参与的科研项目（含科研获奖等情况）

1.国家自然科学基金青年科学基金项目，81703389，绞股蓝中抗乳腺癌新型达玛烷衍生物的发现及其Wnt/β-catenin信号通路调控机制，2018-2021，21万，主持

2.沈阳药科大学中青年发展支持计划，ZQN2016023，绞股蓝中新达玛烷衍生物的发现及Wnt/β-catenin信号通路的调控机制，5万，主持

3.辽宁省教育厅，201610163L35，绞股蓝中抗前列腺癌活性成分的发现及作用机制研究，4万，2016.1-2018.12，主持

4.抗肿瘤一类新药-新人参皂苷元AD-1的临床前研究，2009ZX09102-114，国家“十一五”重大专项，主要完成人

5.中药标准提取物工业化色谱制备技术子平台，2010ZX09102-105B，国家“十一五”重大专项，参与人

近年来发表代表性论文

1.Jiayin Yue, Yuanyuan Sun, Jing Xu, Jiaqing Cao, Gang Chen, Huixing Zhang,Xiaoshu Zhang*, Yuqing Zhao*.Cucurbitane triterpenoids from the fruit of Momordica charantiaL. and theiranti-hepatic fibrosis and anti-hepatoma activities.Phytochemistry.157 (2019) 21–27.（IF 3.2）

2.Yumeng Zhang, Weihui Yuan, Xude Wang,Hongyu Zhang, Yuanyuan Sun,Xiaoshu Zhang*and Yuqing Zhao*.Synthesis, characterization and cytotoxic activityevaluation of ginsengdiol oxidation and nitrogenhybrid derivatives.MedChemComm.DOI: 10.1039/c8md00387d. IF 2.342

3.Jing Xu, Xude Wang, Guangyue Su, Yuanyuan Sun, Jiaqing Cao,Xiaoshu Zhang*, Yuqing Zhao*.The antioxidant and anti-hepatic fibrosis activities of acorns (Quercusliaotungensis ) and their natural galloyl triterpenes.Journal of Functional Foods 46 (2018) 567–578.（IF 3.47）

4.Xiaoshu Zhang, Guohui Shi, Mingbing Liu, Rong Chen, Xiaojun Wu, Yuqing Zhao*.Four new dammarane-type triterpenesderivatives from hydrolyzate of total Gynostemmapentaphyllum saponins and their bioactivities.Natural Product Research. 2018. 1-7. (IF 1.8)

5. Jing Xu, Jiaqing Cao, Jiayin Yue,Xiaoshu Zhang*, Yuqing Zhao*.New triterpenoids from acorns of Quercus liaotungensisand their inhibitoryactivity against α -glucosidase, α -amylase and protein-tyrosine phosphatase.Journal of Functional Foods. 2018, 41:232-239. (IF 3.47)

6. Jing Xu, Jiaqing Cao, Jiayin Yue,Xiaoshu Zhang*, Yuqing Zhao*.New triterpenoids from acorns of Quercus liaotungensisand their inhibitoryactivity against α -glucosidase, α -amylase and protein-tyrosine phosphatase.Journal of Functional Foods. 2018, 41:232-239. (IF 3.47)

7.Xiaoshu Zhang, Guohui Shi, Mingbing Liu, Rong Chen, Xiaojun Wu, Yuqing Zhao*.Four new dammarane-type triterpenesderivatives from hydrolyzate of total Gynostemmapentaphyllum saponins and their bioactivities.Natural Product Research. 2018. 1-7. (IF 1.92)

8.Xiaoshu Zhang, Guohui Shi, Mingbing Liu, Rong Chen, Xiaojun Wu, Yuqing Zhao*.Protective effects of dammarane-type triterpenes from hydrolyzate ofGynostemma pentaphyllumagainst H₂O₂-induced injury and anti-hepaticfibrosis activities.Phytochemistry Letters.25 (2018) 33–36. (IF 1.5)

9. Lu Ma,Yuancai Chen, Xude Wang, Mingzhou Xiong, Yuanyuan Sun,XiaoshuZhang*, Yuqing Zhao*.Design, characterization, and in vitro antiproliferative efficacy of gemcitabineconjugates based on carboxymethyl glucan.Bioorganic & Medicinal Chemistry Letters.28 (2018) 2920–2924. (IF 2.442)

10.Jing Xu, Xude Wang, Jiayin Yue, Yuanyuan Sun,Xiaoshu Zhangand Yuqing Zhao*.Polyphenols from Acorn Leaves (Quercusliaotungensis) Protect Pancreatic Beta Cells and TheirInhibitory Activity againsta-Glucosidase and ProteinTyrosine Phosphatase 1B. Molecules. 2018, 23:2167. (IF 3.2)

11.Guohui Shi, Xude Wang, He Zhang,Xiaoshu Zhang*, Yuqing Zhao*.New dammarane-type triterpene saponins fromGynostemma pentaphyllumand their anti-hepatic fibrosis activities in vitro.Journal of Functional Foods.45 (2018) 10–14. (IF 3.47)

12.Xiaoshu Zhang, Guohui Shi, Yuanyuan Sun, Xiaojun Wu, Yuqing Zhao*. Triterpenes derived from hydrolyzate of total Gynostemma pentaphyllum saponins with anti-hepatic fibrosis and protective activity against H₂O₂-induced injury. Phytochemistry, 2017, 144:226-232.(IF 3.2)

13. Jiayin Yue, Jing Xu, Jiaqing Cao,Xiaoshu Zhang*, Yuqing Zhao*. Cucurbitane triterpenoids from Momordica charantia L. and their inhibitory activity against a-glucosidase, a-amylase and protein tyrosine phosphatase 1B (PTP1B). Journal of Functional Foods.2017, 37:624–631. (共同通讯，IF 3.47)

14.Xiaoshu Zhang, Chen Zhao, Weizhuo Tang, Xiaojun Wu, Yuqing Zhao*. Gypensapogenin H, a novel dammarane-type triterpene induces cell cycle arrest and apoptosis on prostate cancer cells. Steroids. 2015, 104:276–283.(IF 2.68)

15.Xiaoshu Zhang, Jiaqing Cao, Chen Zhao, Xude Wang, Yuqing Zhao*. Novel anti-tumor dammarane-type triterpenes isolated from hydrolyzate of total Gynostemma pentaphyllum saponins. Bioorg & Med Chem Lett. 2015, 25:3095–3099.(IF 2.4)

16.Xiaoshu Zhang, Jiaqing Cao, Zhenting Liu, Lei Yuan, Gang Chen, Jingxin Liu, Fanzhi Qu, Yuqing Zhao. Callistephus A, a novel sesquiterpene from the Callistephus chinensis flower. Phytochemistry Letters. 2015, 11, 5-8.(IF 1.5)

17.Xiaoshu Zhang, Jiaqing Cao, Guohui Shi, Zhenting Liu, Jingxin Liu, Yuqing Zhao*. Two new isoaurones derivatives from Callistephus chinensis flower. Natur Prod Res, 2015, 19(43), 1-4.(IF 1.8)

18.Xiaoshu Zhang, Xiuli Bi, Wan Xiao, Jiaqing Cao, Xichun Xia, Yuqing Zhao*. Protein tyrosine phosphatase 1B inhibitory effect by dammarane-type triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins. Bioorg & Med Chem Lett. 2013, 1(23), 297-300.(IF 2.4)