一、个人简介
贾英,沈阳药科大学药物分析学博士,现任沈阳药科大学功能食品与葡萄酒学院副院长,实验教学中心主任,教授,生药学和中药分析学博士生导师,省级精品课生药学课程负责人。2015年11月-2016年1月在葡萄牙国家农牧研究院葡萄与葡萄酒研究所做高级访问学者。辽宁省中药多糖生物活性评价重点实验室负责人,沈阳市中药药效物质基础筛选与评价重点实验室负责人,兴辽英才高水平创新团队负责人。
二、研究方向
主要从事中药药效物质基础、药食同源品质量控制与质量评价、神经退行性疾病活性成分筛选及中药干预、天然药物、复方中药新药及功能食品开发研究。
三、社会兼职
兼任中国博士后科学基金评审专家,国家自然科学基金函审评议专家,中国补益药学会理事,辽宁省细胞生物学学会理事,辽宁省保健食品安全专业委员会副主任委员,辽宁省中药学会会员,美国质谱学会会员,《沈阳药科大学学报》编委,《中草药》杂志编委,《Journal of Polyphenols》杂志编委。
四、科研成果与获奖
曾先后主持并参与国家、省市各级科研课题20多项,其中主持国家级课题7项,主持省级课题9项,主持市级课题3项,主持横向课题多项;目前正承担国家自然科学基金面上项目(基于多信号通路的五味子抗抑郁、改善睡眠作用机制与“组分-效应”关系研究,项目编号:81573580)。以第一或通讯作者在国内外核心期刊发表论文100多篇,其中SCI收载50余篇。参加编写教材7部;申请国家发明专利11项,授权2项。2013年获沈阳市科学技术进步二等奖1项;2014年获辽宁省科学技术奖励二等奖1项;2015年获沈阳市自然科学学术成果三等奖;2018年获沈阳市自然科学学术成果三等奖。2008年被评为沈阳市科教系统优秀共产党员,2009年入选辽宁省高校班主任(导师)骨干。2016年获评第十二届沈阳市先进科技工作者,2017年获评辽宁省特聘教授,2018年度第四批沈阳市领军人才,沈阳药科大学教学名师,2019年获批辽宁省教学名师,2020年获批兴辽英才高水平创新团队。
五、代表性文章
1.Tingxu Yan, Tingting Nian, Zhengzheng Liao, Feng Xiao, Bo Wu, Kaishun Bi, Bosai He, andYing Jia*. Antidepressant effects of a polysaccharide from okra (Abelmoschus esculentus (L) Moench) by anti-inflammation and rebalancing the gut microbiota. International Journal of Biological Macromolecules. 2020, 144:427-440 (IF:5.162)
2.Tingxu Yan, Nizhi Wang, Bing Liu, Bo Wu, Feng Xiao, Bosai He,Ying Jia*. Schisandra chinensis ameliorates depressive-like behaviors by regulating microbiota-gut-brain axis via its anti-inflammation activity. Phytotherapy Research. 2020, 10.1002/ptr.6799. (IF: 4.087)
3.TingxuYan, TingtingNian, BoWu, FengXiao, BosaiHe, KaishunBi,YingJia*. Okra polysaccharides can reverse the metabolic disorder induced by high-fat diet and cognitive function injury in Aβ1–42 mice. Experimental Gerontology, 130 (2020):110802. (IF:3.376)
4.Tingxu Yan, Yingying Sun, Feng Xiao, Bo Wu, Kaishun Bi, Bosai He,Ying Jia*. Schisandrae Chinensis Fructus inhibits behavioral deficits induced by sleep deprivation and chronic unpredictable mild stress via increased signaling of brain‐derived neurotrophic factor. Phytotherapy Research. 2019, 33(12):3177-3190. (IF: 4.087)
5.Tingxu Yan, Bosai He, Mengjie Xu, Bo Wu, Feng Xiao, Kaishun Bi,Ying Jia*. Kaempferide prevents cognitive decline via attenuation of oxidative stress and enhancement of brain‐derived neurotrophic factor/tropomyosin receptor kinase B/cAMP response element-binding signaling pathway. Phytotherapy Reasearch 2019:1-9.(IF: 4.087)
6.Tingxu Yan, Fuyuan Li, Weilin Xiong, Bo Wu, Feng Xiao, Bosai He,Ying Jia*. Nootkatone improves anxiety‐and depression‐like behavior by targeting hyperammonemia-induced oxidative stress in D-galactosamine model of liver injury. Environmental Toxicology https://doi.org/10.1002/tox.23073 (IF:3.118)
7.Yu Qi, Xinhui Cheng, Huiting Jing, Tingxu Yan, Feng xiao, Bo Wu, Kaishun Bi*,Ying Jia*. Effect of Alpinia oxyphylla—Schisandra chinensis herb pair on inflammation and apoptosis in Alzheimer’s disease mice model. Journal of Ethnopharmacology. Journal of Ethnopharmacology 237 (2019) 28–38.
8.Tingxu Yan, Yingying Sun, Guowei Gong, Yue Li, Kaiyue Fan, Bo Wu, Kaishun Bi,Ying Jia*. The neuroprotective effect of Schisandrol A on 6-OHDA-induced PD mice may be related to PI3K/AKT and IKK/IκBα/NF-κB pathway. Experimental Gerontology, 128 (2019): 110743. (IF:3.376)
9.Mengjie Xu, Tingxu Yan, Kaiyue Fan, Mengshi Wang, Yu Qi, Feng Xiao, Kaishun Bi,Ying Jia*.Polysaccharide of Schisandra Chinensis Fructus ameliorates cognitive decline in a mouse model of Alzheimer's disease. Journal of Ethnopharmacology.https://doi.org/10.1016/j.jep.2019.02.046.
10.Bosai He, Fanxing Xu, Tingxu Yan, Feng Xiao, Bo Wu, Yunlong Wang, Kaishun Bi,Ying Jia*, Tectochrysin from Alpinia Oxyphylla Miq. alleviates Aβ1–42 induced learning and memory impairments in mice. European Journal of Pharmacology, 842 (2019) 365–372.