徐静，女，博士，副研究员，2018年毕业于沈阳药科大学，获博士学位，同年进入沈阳药科大学中药学科博士后流动站继续开展科研工作，2020年留校任教，主要研究方向为功能食品的物质基础及作用机制研究等。作为课题负责人主持国家自然科学基金青年基金1项。另外，作为主要完成人参与国家“十一五”重大专项1项，国家“十一五”重大专项子平台项目1项。目前已在Journal of Agricultural and Food Chemistry、Journal of Functional Food、Journal of Ethnopharmacology等期刊发表论文20余篇。

主要研究方向

研究方向一：保健食品及功能性食品的物质基础研究

研究方向二：具有调控糖脂代谢紊乱的天然功能因子的发现与制备

研究方向三：抗糖脂代谢紊乱功能因子的作用机制研究

社会兼职

《中草药》杂志青年编委

科研项目

1.基于AMPK靶点的糖脂代谢紊乱调节剂—新达玛烷T19及其衍生物的发现，国家自然科学基金青年基金(81903518)，主持

2.辽宁省天然创新药物（原料）工业化制备技术工程研究中心（2017-1007），辽宁省工程研究中心项目，主要参与人

3.抗肿瘤一类新药-新人参皂苷元AD-1的临床前研究，2009ZX09102-114，国家“十一五”重大专项，主要参与人

4.中药标准提取物工业化色谱制备技术子平台，2010ZX09102-105B，国家“十一五”重大专项，主要参与人

近年来发表代表性论文

1.Jing Xu, Tao Li, Xiaoyan Xia, Chaofan Fu, Xude Wang,* Yuqing Zhao*. Dietary Ginsenoside T19 Supplementation Regulates Glucose and Lipid Metabolism via AMPK and PI3K Pathways and Its Effect on Intestinal Microbiota. Journal of Agricultural and Food Chemistry. 2020, 68: 14452−14462.(IF=4.192)

2.Jing Xu, Chaofan Fu, Tao Li, Xiaoyan Xia, Huixing Zhang, Xude Wang*, and Yuqing Zhao*,Protective effect of acorn (Quercus liaotungensisKoidz) on streptozotocin-damaged MIN6 cells and type 2 diabetic rats via p38 MAPK/Nrf2/HO-1 pathway.Journal of Ethnopharmacology.2021, 266:113444.(IF=3.69)

3.Jing Xu^#, Hairong Liu^#, Guangyue Su, Meng Ding, Wei Wang, Jincai Lu*,Xiuli Bi*, Yuqing Zhao*. Purification of ginseng rare sapogenins 25-OH-PPT and its hypoglycemic, antiinflammatory and lipid-lowering mechanisms. Journal of Ginseng Research. 2021, 45: 86-97. (IF=5.487)

4.Jing Xu, Xude Wang, Hongyu Zhang, Jiayin Yue, Yuanyuan Sun, Xiaoshu Zhang*, Yuqing Zhao*, Synthesis of triterpenoid derivatives and their anti-tumor and anti-hepatic fibrosis activities. Natural Product Research. 2020. 34(6):766-772. (IF=2.158)

5.Jing Xu, Jiaqing Cao, Jiayin Yue, Xiaoshu Zhang*, Yuqing Zhao*. New triterpenoids from acorns of Quercus liaotungensis and their inhibitory activity against a-glucosidase, a-amylase and protein-tyrosine phosphatase 1B. Journal of Functional Foods. 2018,41: 232-239.(IF=3.197)

6.Jing Xu, Xude Wang, Guangyue Su, Jiayin Yue, Yuanyuan Sun, Jiaqing Cao, Xiaoshu Zhang*, Yuqing Zhao*. The antioxidant and anti-hepatic fibrosis activities of acorns (Quercusliaotungensis) and their natural galloyl triterpenes. Journal of Functional Foods. 2018,46: 567-578. (IF=3.197)

7.Jing Xu, Xude Wang, Jiayin Yue, Yuanyuan Sun, Xiaoshu Zhang*, Yuqing Zhao*. Polyphenols from acorn leaves (Quercus liaotungensis) protect pancreatic beta cells against oxidative stress-induced damageand and their inhibitory activity against α-glucosidase and PTP1B. Molecules. 2018,23:2167. (IF=3.06)

8.Lu Ma^#, Xude Wang^#, Wei Li, Tao Li, Shengnan Xiao, Jincai Lu,Jing Xu*, Yuqing Zhao*, Rational design, synthesis and biological evaluation of triphenylphosphonium-ginsenoside conjugates as mitochondria-targeting anti-cancer agents. Bioorganic Chemistry. 2020, 103: 104150. (IF=4.831)

9.Xiaoyan Xia, Xude Wang, Hua Wang, Zhenchuan Lin, Keping Shao,Jing Xu*, Yuqing Zhao*, Ameliorative effect of white tea from 50-year-old tree of Camellia sinensis L. (Theaceae) on kidney damage in diabetic mice via SIRT1/AMPK pathway. Journal of Ethnopharmacology.2021, 272:113919.(IF=3.69)

10.Zhonghua Luo, Chaofan Fu, Tao Li, Qingqing Gao, Dongyu Miao,Jing Xu*,and Yuqing Zhao*, Hypoglycemic Effects of Licochalcone A on the StreptozotocinInduced Diabetic Mice and Its Mechanism Study.2021, 69:2444−2456.(IF=4.192)